Radiation-induced bowel injury

Thrive Health

Radiation-induced bowel injury: the impact of radiotherapy on survivorship after treatment for gynaecological cancers

S Kuku, C Fragkos, M McCormack and A Forbes

British Journal of Cancer 109, 1504-1512 (17 September 2013) | doi:10.1038/bjc.2013.491

Background:

The number of women surviving cancer who live with symptoms of bowel toxicity affecting their quality of life continues to rise. In this retrospective study, we sought to describe and analyse the presenting clinical features in our cohort, and evaluate possible predictors of severity and chronicity in women with radiation-induced bowel injury after treatment for cervical and endometrial cancers.

Posterior half of uterus and upper part of vag...

Methods:

Review of records of 541 women treated within the North London Gynaecological Cancer Network between 2003 and 2010 with radiotherapy with or without chemotherapy for cervical and endometrial cancer identified 152 women who reported significant new bowel symptoms after pelvic radiation.

Results:

Factor analysis showed that the 14 most common and…

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